If you are more a fan of sketching on paper, you can actually do so and scan the sketch to Adobe Photoshop. If you have invested in a graphics tablet, you can sketch directly into the program, so you can still practice the art of drawing, but capturing it digitally from start to finish. The program offers all the high-quality tools you would need to create incredible manga and anime styled work.
Adobe Photoshop has to be one of the most popular programs on the market, specifically for drawing and painting digitally.